Publications of the Psoriasis Research and Treatment Center

Authors:Sabat R, Šimaitė D, Gudjonsson JE, Brembach TC, Witte K, Krause T,
Kokolakis G, Bartnik E, Nikolaou C, Rill N, Coulibaly B, Levin C, Herrmann M,
Salinas G, Leeuw T, Volk HD, Ghoreschi K, Wolk K.

Title:Neutrophilic granulocyte-derived B-cell activating factor supports B cells in skin lesions in hidradenitis suppurativa

Journal:J Allergy Clin Immunol. Year:2022; :Pages:S0091-6749(22)01621-9.

Authors:Witte K, Sabat R, Witte-Händel E, Ghoreschi K, Wolk K.

Title:Phytotherapeuthics Affecting the IL-1/IL-17/G-CSF Axis: A Complementary Treatment Option for Hidradenitis Suppurativa?

Journal:Int J Mol Sci. Year:2022; Volume:23Issue:(16):Pages:9057.

Authors:Wolk K, Brembach TC, Šimaitė D, Bartnik E, Cucinotta S, Pokrywka A,
Irmer ML, Triebus J, Witte-Händel E, Salinas G, Leeuw T, Volk HD,
Ghoreschi K, Sabat R.

Title:Activity and components of the granulocyte colony-stimulating factor pathway in hidradenitis suppurativa

Journal:Br J Dermatol. Year:2021; Volume:185Issue:(1):Pages:164-176.

Authors:Ghoreschi K, Balato A, Enerbäck C, Sabat R.

Title:Therapeutics targeting the IL-23 and IL-17 pathway in psoriasis

Journal:Lancet. Year:2021; Volume:397Issue:(10275):Pages:754-766.

Authors:Wolk K, Join-Lambert O, Sabat R.

Title:Aetiology and pathogenesis of hidradenitis suppurativa

Journal:Br J Dermatol. Year:2021; Volume:183Issue:(6):Pages:999-1010.

Authors:Kokolakis G, Wolk K, Schneider-Burrus S, Kalus S, Barbus S,
Gomis-Kleindienst S, Sabat R.

Title:Delayed Diagnosis of Hidradenitis Suppurativa and Its Effect on Patients and Healthcare System

Journal:Dermatology. Year:2020; Volume:236Issue:(5):Pages:421-430.

Authors:Sabat R, Jemec GBE, Matusiak Ł, Kimball AB, Prens E, Wolk K.

Title:Hidradenitis suppurativa

Journal:Nat Rev Dis Primers. Year:2020; Volume:6Issue:(1):Pages:18.

Authors:Loyal L, Warth S, Jürchott K, Mölder F, Nikolaou C, Babel N, Nienen N, Durlanik S, Stark R,
Kruse B, Frentsch M, Sabat R, Wolk K, Thiel A.

Title:SLAMF7 and IL-6R define distinct cytotoxic versus helper memory CD8+ T cells

Journal:Nat Commun. Year:2020; Volume:11Issue:(1):Pages:6357.

Authors:Kokolakis G, Wolk K, Schneider-Burrus S, Kalus S, Barbus S, Gomis-Kleindienst S, Sabat R.

Title:Delayed Diagnosis of Hidradenitis Suppurativa and Its Effect on Patients and Healthcare System

Journal:Dermatology. Year:2020; Volume:236Issue:(5):Pages:421-430.

Authors:Kokolakis G, Bachmann F, Wolk K, Sabat R, Philipp S.

Title:Efficacy of Adalimumab for Nail Psoriasis During 24 Months of Continuous Therapy

Journal:Acta Derm Venereol. Year:2020; Volume:100Issue:(14)

Authors:Delić D, Wolk K, Schmid R, Gabrielyan O, Christou D, Rieber K, Rolser M, Jakob I, Wiech F, Griesser M, Wohnhaas C, Kokolakis G, Witte-Händel E, Baum P, Sabat R.

Title: Integrated microRNA/mRNA expression profiling of the skin of psoriasis patients

Journal:J Dermatol Sci. Year:2020; Volume:97Issue:(1):Pages:9-20.

Authors:Witte K, Jürchott K, Christou D, Hecht J, Salinas G, Krüger U, Klein O,
Kokolakis G, Witte-Händel E, Mössner R, Volk HD, Wolk K, Sabat R.

Title:Increased presence and differential molecular imprinting of transit amplifying cells in psoriasis

Journal:J Mol Med (Berl). Year:2020; Volume:98Issue:(1):Pages:111-122.

Authors:Sabat R, Wolk K, Loyal L, Döcke WD, Ghoreschi K.

Title: T cell pathology in skin inflammation

Journal:Semin Immunopathol. Year:2019; Volume:41Issue:(3):Pages:359-377.

Authors:Krause K, Sabat R, Witte-Händel E, Schulze A, Puhl V, Maurer M, Wolk K.

Title:Association of CCL2 with systemic inflammation in Schnitzler syndrome

Journal:Br J Dermatol. Year:2019; Volume:180Issue:(4):Pages:859-868.

Authors:Witte-Händel E, Wolk K, Tsaousi A, Irmer ML, Mößner R, Shomroni O,
Lingner T, Witte K, Kunkel D, Salinas G, Jodl S, Schmidt N, Sterry W, Volk HD,
Giamarellos-Bourboulis EJ, Pokrywka A, Döcke WD, Schneider-Burrus S, Sabat R.

Title: The IL-1 Pathway Is Hyperactive in Hidradenitis Suppurativa and Contributes to Skin Infiltration and Destruction

Journal:J Invest Dermatol . Year:2019; Volume:139Issue:(6):Pages:1294-1305.

Authors:Wittig BM, Sabat R, Holzlöhner P, Witte-Händel E, Heilmann K, Witte K,
Triebus J, Tzankov A, Laman JD, Bokemeyer B, Terracciano L, Schwärzler C,
Kohler H, Volkmer R, Loddenkemper C, Wolk K, Hoffmann U, Günthert U.

Title: Absence of specific alternatively spliced exon of CD44 in macrophages prevents colitis

Journal:Mucosal Immunol. Year:2017; Volume:11Issue:(3):Pages:846-860.

Authors:Zouboulis CC, Tzellos T, Kyrgidis A, Jemec GBE, Bechara FG, Giamarellos-Bourboulis EJ,
Ingram JR, Kanni T, Karagiannidis I, Martorell A, Matusiak Ł, Pinter A, Prens EP, Presser D,
Schneider-Burrus S, von Stebut E, Szepietowski JC, van der Zee HH, Wilden SM, Sabat R;
European Hidradenitis Suppurativa Foundation Investigator Group.

Title:Development and validation of the International Hidradenitis Suppurativa Severity Score System (IHS4), a novel dynamic scoring system to assess HS severity

Journal:Br J Dermatol. Year:2017; Volume:117Issue:(5):Pages:1401-1409.

Authors:Martin JC, Wolk K, Bériou G, Abidi A, Witte-Händel E, Louvet C, Kokolakis G,
Drujont L, Dumoutier L, Renauld JC, Sabat R, Josien R.

Title: Limited Presence of IL-22 Binding Protein, a Natural IL-22 Inhibitor, Strengthens Psoriatic Skin Inflammation

Journal:J Immunol. Year:2017; Volume:198Issue:(9):Pages:3671-3678.

Authors:Wolk K, Wenzel J, Tsaousi A, Witte-Händel E, Babel N, Zelenak C, Volk HD,
Sterry W, Schneider-Burrus S, Sabat R.

Title:Lipocalin-2 is expressed by activated granulocytes and keratinocytes in affected skin and reflects disease activity in acne inversa/hidradenitis suppurativa

Journal:Br J Dermatol. Year:2017; Volume:177Issue:(5):Pages:1385-1393.

Authors:Wolk K, Sabat R.

Title:Adipokines in psoriasis: An important link between skin inflammation and metabolic alterations

Journal:Rev Endocr Metab Disord. Year:2016; Volume:17Issue:(3):Pages:305-317.

Authors:Witte E, Kokolakis G, Witte K, Warszawska K, Friedrich M, Christou D,
Kirsch S, Sterry W, Volk HD, Sabat R, Wolk K.

Title: Interleukin-29 induces epithelial production of CXCR3A ligands and T-cell infiltration

Journal:J Mol Med (Berl). Year:2016; Volume:94Issue:(4):Pages:391-400.

Authors:Sabat R, Ouyang W, Wolk K.

Title:Therapeutic opportunities of the IL-22-IL-22R1 system

Journal:Nat Rev Drug Discov. Year:2014; Volume:13Issue:(1):Pages:21-38.

Authors:Wolk K, Mitsui H, Witte K, Gellrich S, Gulati N, Humme D, Witte E,
Gonsior M, Beyer M, Kadin ME, Volk HD, Krueger JG, Sterry W, Sabat R.

Title:Deficient cutaneous antibacterial competence in cutaneous T-cell lymphomas: role of Th2-mediated biased Th17 function

Journal:Clin Cancer Res. Year:2014; Volume:20Issue:(21):Pages:5507-5516.

Authors:Witte E, Kokolakis G, Witte K, Philipp S, Doecke WD, Babel N,
Wittig BM, Warszawska K, Kurek A, Erdmann-Keding M, Kunz S,
Asadullah K, Kadin ME, Volk HD, Sterry W, Wolk K, Sabat R.

Title: IL-19 is a component of the pathogenetic IL-23/IL-17 cascade in psoriasis

Journal:J Invest Dermatol. Year:2014; Volume:134Issue:(11):Pages:2757-2767.

Authors:Sabat R, Ouyang W, Wolk K.

Title:Therapeutic opportunities of the IL-22-IL-22R1 system

Journal:Nat Rev Drug Discov. Year:2014; Volume:13Issue:(1):Pages:21-38.

Authors:Wolk K, Mitsui H, Witte K, Gellrich S, Gulati N, Humme D, Witte E,
Gonsior M, Beyer M, Kadin ME, Volk HD, Krueger JG, Sterry W, Sabat R.

Title:Deficient cutaneous antibacterial competence in cutaneous T-cell lymphomas: role of Th2-mediated biased Th17 function

Journal:Clin Cancer Res. Year:2014; Volume:20Issue:(21):Pages:5507-5516.

Authors:Witte E, Kokolakis G, Witte K, Philipp S, Doecke WD, Babel N,
Wittig BM, Warszawska K, Kurek A, Erdmann-Keding M, Kunz S,
Asadullah K, Kadin ME, Volk HD, Sterry W, Wolk K, Sabat R.

Title: IL-19 is a component of the pathogenetic IL-23/IL-17 cascade in psoriasis

Journal:J Invest Dermatol. Year:2014; Volume:134Issue:(11):Pages:2757-2767.

Authors:Wolk K, Witte K, Witte E, Raftery M, Kokolakis G, Philipp S, Schönrich G,
Warszawska K, Kirsch S, Prösch S, Sterry W, Volk HD, Sabat R.

Title:IL-29 is produced by T(H)17 cells and mediates the cutaneous antiviral competence in psoriasis

Journal:Sci Transl Med. Year:2013; Volume:5Issue:(204):Pages:204ra129.

Authors:Kumari S, Bonnet MC, Ulvmar MH, Wolk K, Karagianni N, Witte E,
Uthoff-Hachenberg C, Renauld JC, Kollias G, Toftgard R, Sabat R,
Pasparakis M, Haase I.

Title: Tumor necrosis factor receptor signaling in keratinocytes triggers interleukin-24-dependent psoriasis-like skin inflammation in mice

Journal:Immunity. Year:2013; Volume:39Issue:(5):Pages:899-911.

Authors:Sabat R, Chanwangpong A, Schneider-Burrus S, Metternich D,
Kokolakis G, Kurek A, Philipp S, Uribe D, Wolk K, Sterry W.

Title: Increased prevalence of metabolic syndrome in patients with acne inversa

Journal:PLoS One. Year:2012; Volume:7Issue:(2):Pages:e31810.

Authors:Wolk K, Warszawska K, Hoeflich C, Witte E, Schneider-Burrus S,
Witte K, Kunz S, Buss A, Roewert HJ, Krause M, Lukowsky A, Volk HD,
Sterry W, Sabat R.

Title:Deficiency of IL-22 contributes to a chronic inflammatory disease: pathogenetic mechanisms in acne inversa

Journal:J Immunol. Year:2011; Volume:186Issue:(2):Pages:1228-1239.

Authors:Muñoz M, Heimesaat MM, Danker K, Struck D, Lohmann U, Plickert R,
Bereswill S, Fischer A, Dunay IR, Wolk K, Loddenkemper C, Krell HW,
Libert C, Lund LR, Frey O, Hölscher C, Iwakura Y, Ghilardi N, Ouyang W,
Kamradt T, Sabat R, Liesenfeld O.

Title:Interleukin (IL)-23 mediates Toxoplasma gondii-induced immunopathology in the gut via matrixmetalloproteinase-2 and IL-22 but independent of IL-17

Journal:J Exp Med. Year:2009; Volume:206Issue:(13):Pages:3047-3059.

Authors:Wolk K, Witte E, Warszawska K, Schulze-Tanzil G, Witte K, Philipp S,
Kunz S, Döcke WD, Asadullah K, Volk HD, Sterry W, Sabat R.

Title:The Th17 cytokine IL-22 induces IL-20 production in keratinocytes: a novel immunological cascade with potential relevance in psoriasis

Journal:Eur J Immunol . Year:2009; Volume:39Issue:(12):Pages:3570-3581.

Authors:Witte K, Gruetz G, Volk HD, Looman AC, Asadullah K, Sterry W, Sabat R,
Wolk K.

Title:Despite IFN-lambda receptor expression, blood immune cells, but not keratinocytes or melanocytes, have an impaired response to type III interferons: implications for therapeutic applications of these cytokines

Journal:Genes Immun. Year:2009; Volume:10Issue:(8):Pages:702-714.

Authors:Wolk K, Haugen HS, Xu W, Witte E, Waggie K, Anderson M, Vom Baur E,
Witte K, Warszawska K, Philipp S, Johnson-Leger C, Volk HD, Sterry W,
Sabat R.

Title: IL-22 and IL-20 are key mediators of the epidermal alterations in psoriasis while IL-17 and IFN-gamma are not

Journal:J Mol Med (Berl). Year:2009; Volume:87Issue:(5):Pages:523-536.

Authors:Wolk K, Höflich C, Zuckermann-Becker H, Döcke WD, Volk HD, Sabat R.

Title:Reduced monocyte CD86 expression in postinflammatory immunodeficiency

Journal:Crit Care Med. Year:2007; Volume:35Issue:(2):Pages:458-467.

Authors:Wolk K, Witte E, Wallace E, Döcke WD, Kunz S, Asadullah K, Volk HD,
Sterry W, Sabat R.

Title:IL-22 regulates the expression of genes responsible for antimicrobial defense, cellular differentiation, and mobility in keratinocytes: a potential role in psoriasis

Journal:Eur J Immunol. Year:2006; Volume:36Issue:(5):Pages:1309-1323.

Authors:Weiss B, Wolk K, Grünberg BH, Volk HD, Sterry W, Asadullah K, Sabat R.

Title:Cloning of murine IL-22 receptor alpha 2 and comparison with its human counterpart

Journal:Genes Immun. Year:2004; Volume:5Issue:(5):Pages:330-336.

Authors:Wolk K, Kunz S, Witte E, Friedrich M, Asadullah K, Sabat R.

Title:IL-22 increases the innate immunity of tissues

Journal:Immunity. Year:2004; Volume:21Issue:(2):Pages:241-254.