Meta menu:

From here, you can access the Emergencies page, Contact Us page, Accessibility Settings, Language Selection, and Search page.

Open Menu

Working group Seifert

The research group conducts research in the field of cell and tissue transplantation and investigates the mechanisms of immunological recognition and modulation.

You are here:

Monitoring and Modulation of Immune Responses to Cell and Tissue Transplants

“We aim to unravel the complex molecular language between regenerative cells or their derivatives with the body´s main players of immune responses, which will ultimately enable safe and effective therapies and promote the discovery of new therapeutic avenues.”


  • Friede Springer Herzstiftung (2015- 2018)
  • DFG Project 657/12-1 (2015-2019)
  • EU Project PACE (2016-2021)
  • Einstein Center Regenerative Medicine (ECRT), grant (2017-2019)

Techniques & services

  • Primary human cell cultures (endothelial cells, mesenchymal stromal cells, cardiac cells, tenocytes)
  • Isolation of extracellular vesicles (EVs) by differential ultracentrifugation, characterization (EM, flow cytometry, protein/BCA, NTA)
  • Immune cell isolation, separation and co-culture assays
  • Flow cytometry analysis
  • Fluorescence microscopy/ High Content Screening
  • Proliferation assays
  • Cytotoxicity assays
  • Immune cell migration
  • Apoptosis Assays
  • Monocyte/Macrophage/Dendritic cell differentiation/polarization assay
  • Endothelial assays (e.g. activation, angiogenesis)
  • Cytokine/Chemokine/Growth factor detection assays (ELISA & Multiplex assays)
  • Quantitative real time RT-PCR (mRNA; miRNA)
  • Nanostring assays (human Myeloid Panel, human miRNA Panel)
  • Immune histology
  • Raster electron microscopy (REM)
  • Humanized mouse models

Contact details

Prof. Martina Seifert

t: +49 30 450 539 435
f: +49 30 450 539 933