Publikationen der AG Sawitzki

An dieser Stelle finden Sie eine Auswahl der Publikationen zum Thema Molekulare Immunmodulation der AG Sawitzki.

Sie befinden sich hier:

Im Folgenden finden Sie eine Auswahl der Publikationen der letzten Jahre (2015-2018).
Die komplette Publikationsliste finden Sie hier.

2018

  • Blazquez-Navarro A, Dang-Heine C, Wittenbrink N, Bauer C, Wolk K, Sabat R, Westhoff TH, Sawitzki B, Reinke P, Thomusch O, Hugo C, Or-Guil M, Babel N. BKV, CMV, and EBV Interactions and their Effect on Graft Function One Year Post-Renal Transplantation: Results from a Large Multi-Centre Study. EBioMedicine. 2018 Jul 30. pii: S2352-3964(18)30260-3. doi: 10.1016/j.ebiom.2018.07.017.
  • Riquelme P, Haarer J, Kammler A, Walter L, Tomiuk S, Ahrens N, Goecze I, Wege AK, Zecher D, Fändrich F, Schlitt HJ, Banas B, Lutz MB, Kekarainen T, Sawitzki B, Ochando J, Geissler EK, Hutchinson JA. Generation of TIGIT+ Tregs by Human Regulatory Macrophages Before Kidney Transplantation, Nature Communications. 2018. Jul 20;9(1):2858. doi: 10.1038/s41467-018-05167-8.
  • Stanko K, Schumann J, Vogt K, Schlickeiser S, Appelt A, Iwert C, Romagnani C, Jürchott K, Willimsky G, Kühl A, Sawitzki B. CD96 expression defines inflammatory potential of IL-9 producing T helper cells, PNAS. 2018. Mar 27;115(13):E2940-E2949. doi: 10.1073/pnas.1708329115.
  • Nowak A, Lock D, Bacher P, Hohnstein T, Vogt K, Gottfreund J, Giehr P, Polansky JK, Sawitzki B, Kaiser A, Walter J, Scheffold A. CD137+CD154- Expression As a Regulatory T Cell (Treg)-Specific Activation Signature for Identification and Sorting of Stable Human Tregs from In Vitro Expansion Cultures. Front Immunol. 2018 Feb 7;9:199. doi: 10.3389/fimmu.2018.00199. eCollection 2018.
  • Fuchs A, Gliwiński M, Grageda N, Spiering R, Abbas AK, Appel S, Bacchetta R, Battaglia M, Berglund D, Blazar B, Bluestone JA, Bornhäuser M, Ten Brinke A, Brusko TM, Cools N, Cuturi MC, Geissler E, Giannoukakis N, Gołab K, Hafler DA, van Ham SM, Hester J, Hippen K, Di Ianni M, Ilic N, Isaacs J, Issa F, Iwaszkiewicz-Grześ D, Jaeckel E, Joosten I, Klatzmann D, Koenen H, van Kooten C, Korsgren O, Kretschmer K, Levings M, Marek-Trzonkowska NM, Martinez-Llordella M, Miljkovic D, Mills KHG, Miranda JP, Piccirillo CA, Putnam AL, Ritter T, Roncarolo MG, Sakaguchi S, Sánchez-Ramón S, Sawitzki B, Sofronic-Milosavljevic L, Sykes M, Tang Q, Vives-Pi M, Waldmann H, Witkowski P, Wood KJ, Gregori S, Hilkens CMU, Lombardi G, Lord P, Martinez-Caceres EM, Trzonkowski P. Minimum Information about T Regulatory Cells: A Step toward Reproducibility and Standardization. Front Immunol. 2018 Jan 15;8:1844. doi: 10.3389/fimmu.2017.01844. eCollection 2017.
  • Tabares P, Berr S, Langenhorst D, Sawitzki B, Ten Berge I, Tony HP, Hünig T. Short-term cytokine stimulation reveals regulatory T cells with down-regulated Foxp3 expression in human peripheral blood. Eur J Immunol. 2018 Feb;48(2):366-379. doi: 10.1002/eji.201747244. 2017

2017

  • Cossarizza A, Chang HD, Radbruch A, Akdis M, Andrä I, Annunziato F, Bacher P, Barnaba V, Battistini L, Bauer WM, Baumgart S, Becher B, Beisker W, Berek C, Blanco A, Borsellino G, Boulais PE, Brinkman RR, Büscher M, Busch DH, Bushnell TP, Cao X, Cavani A, Chattopadhyay PK, Cheng Q, Chow S, Clerici M, Cooke A, Cosma A, Cosmi L, Cumano A, Dang VD, Davies D, De Biasi S, Del Zotto G, Della Bella S, Dellabona P, Deniz G, Dessing M, Diefenbach A, Di Santo J, Dieli F, Dolf A, Donnenberg VS, Dörner T, Ehrhardt GRA, Endl E, Engel P, Engelhardt B, Esser C, Everts B, Dreher A, Falk CS, Fehniger TA, Filby A, Fillatreau S, Follo M, Förster I, Foster J, Foulds GA, Frenette PS, Galbraith D, Garbi N, García-Godoy MD, Geginat J, Ghoreschi K, Gibellini L, Goettlinger C, Goodyear CS, Gori A, Grogan J, Gross M, Grützkau A, Grummitt D, Hahn J, Hammer Q, Hauser AE, Haviland DL, Hedley D, Herrera G, Herrmann M, Hiepe F, Holland T, Hombrink P, Houston JP, Hoyer BF, Huang B, Hunter CA, Iannone A, Jäck HM, Jávega B, Jonjic S, Juelke K, Jung S, Kaiser T, Kalina T, Keller B, Khan S, Kienhöfer D, Kroneis T, Kunkel D, Kurts C, Kvistborg P, Lannigan J, Lantz O, Larbi A, LeibundGut-Landmann S, Leipold MD, Levings MK, Litwin V, Liu Y, Lohoff M, Lombardi G, Lopez L, Lovett-Racke A, Lubberts E, Ludewig B, Lugli E, Maecker HT, Martrus G, Matarese G, Maueröder C, McGrath M, McInnes I, Mei HE, Melchers F, Melzer S, Mielenz D, Mills K, Mirrer D, Mjösberg J, Moore J, Moran B, Moretta A, Moretta L, Mosmann TR, Müller S, Müller W, Münz C, Multhoff G, Munoz LE, Murphy KM, Nakayama T, Nasi M, Neudörfl C, Nolan J, Nourshargh S, O'Connor JE, Ouyang W, Oxenius A, Palankar R, Panse I, Peterson P, Peth C, Petriz J, Philips D, Pickl W, Piconese S, Pinti M, Pockley AG, Podolska MJ, Pucillo C, Quataert SA, Radstake TRDJ, Rajwa B, Rebhahn JA, Recktenwald D, Remmerswaal EBM, Rezvani K, Rico LG, Robinson JP, Romagnani C, Rubartelli A, Ruckert B, Ruland J, Sakaguchi S, Sala-de-Oyanguren F, Samstag Y, Sanderson S, Sawitzki B, Scheffold A, Schiemann M, Schildberg F, Schimisky E, Schmid SA, Schmitt S, Schober K, Schüler T, Schulz AR, Schumacher T, Scotta C, Shankey TV, Shemer A, Simon AK, Spidlen J, Stall AM, Stark R, Stehle C, Stein M, Steinmetz T, Stockinger H, Takahama Y, Tarnok A, Tian Z, Toldi G, Tornack J, Traggiai E, Trotter J, Ulrich H, van der Braber M, van Lier RAW, Veldhoen M, Vento-Asturias S, Vieira P, Voehringer D, Volk HD, von Volkmann K, Waisman A, Walker R, Ward MD, Warnatz K, Warth S, Watson JV, Watzl C, Wegener L, Wiedemann A, Wienands J, Willimsky G, Wing J, Wurst P, Yu L, Yue A, Zhang Q, Zhao Y, Ziegler S, Zimmermann J. Guidelines for the use of flow cytometry and cell sorting in immunological studies. Eur J Immunol. 2017 Oct;47(10):1584-1797. doi: 10.1002/eji.201646632.
  • Marek-Trzonkowska N, Piekarska K, Filipowicz N, Piotrowski A, Gucwa M, Vogt K, Sawitzki B, Siebert J, Trzonkowski P. Mild hypothermia provides Treg stability. Sci Rep. 2017 Sep 20;7(1):11915. doi: 10.1038/s41598-017-10151-1. Erratum in: Sci Rep. 2017 Dec 15;7(1):17940.
  • Mundt S, Basler M, Sawitzki B, Groettrup M. No prolongation of skin allograft survival by immunoproteasome inhibition in mice. Mol Immunol. 2017 Aug;88:32-37. doi: 10.1016/j.molimm.2017.05.022.
  • Belaschk E, Rohn S, Mukiibi R, Reutzel-Selke A, Tang P, Sawitzki B, Pratschke J, Sauer IM, Mogl MT. Isolation, characterization and cold storage of cells isolated from diseased explanted livers. Int J Artif Organs. 2017 Jun 9;40(6):294-306. doi: 10.5301/ijao.5000594.
  • Viklicky O, Hruba P, Tomiuk S, Schmitz S, Gerstmayer B, Sawitzki B, Miqueu P, Mrazova P, Tycova I, Svobodova E, Honsova E, Janssen U, Volk HD, Reinke P. Sequential Targeting of CD52 and TNF Allows Early Minimization Therapy in Kidney Transplantation: From a Biomarker to Targeting in a Proof-Of-Concept Trial. PLoS One. 2017 Jan 13;12(1):e0169624. doi: 10.1371/journal.pone.0169624. eCollection 2017.
  • Stanko K, Sawitzki B. IRF1 and BATF – transcription factors setting the epigenetic landscape for Tr1 differentiation? Research highlight, Cellular & Molecular Immunology, 2017 Jul 10. Doi: 10.1038/cmi. 2017.50
  • Behnam-Sani K, Sawitzki B. Immune Monitoring as Prerequisite for Transplantation Tolerance Trials. Clin Exp Immunol. 2017 May 18. doi: 10.1111/cei.12988. [Epub ahead of print] Review. PubMed PMID: 28518214.

2016

  • Durek P, Nordström K, Gasparoni G, Salhab A, Kressler C, de Almeida M, Bassler K, Ulas T, Schmidt F, Xiong J, Glažar P, Klironomos F, Sinha A, Kinkley S, Yang X, Arrigoni L, Amirabad AD, Ardakani FB, Feuerbach L, Gorka O, Ebert P, Müller F, Li N, Frischbutter S, Schlickeiser S, Cendon C, Fröhler S, Felder B, Gasparoni N, Imbusch CD, Hutter B, Zipprich G, Tauchmann Y, Reinke S, Wassilew G, Hoffmann U, Richter AS, Sieverling L; DEEP Consortium., Chang HD, Syrbe U, Kalus U, Eils J, Brors B, Manke T, Ruland J, Lengauer T, Rajewsky N, Chen W, Dong J, Sawitzki B, Chung HR, Rosenstiel P, Schulz MH, Schultze JL, Radbruch A, Walter J, Hamann A, Polansky JK. Epigenomic Profiling of Human CD4(+) T Cells Supports a Linear Differentiation Model and Highlights Molecular Regulators of Memory Development. Immunity. 2016 Nov 15;45(5):1148-1161.
  • Bacher P, Heinrich F, Stervbo U, Nienen M, Vahldieck M, Iwert C, Vogt K, Kollet J, Babel N, Sawitzki B, Schwarz C, Bereswill S, Heimesaat MM, Heine G, Gadermaier G, Asam C, Assenmacher M, Kniemeyer O, Brakhage AA, Ferreira F, Wallner M, Worm M, Scheffold A. Regulatory T Cell Specificity Directs Tolerance versus Allergy against Aeroantigens in Humans. Cell. 2016 Nov 3;167(4):1067-1078.e16.
  • Gerlach UA, Klöpfel M, Atanasov G, Polenz D, Vogt K, Ahrlich S, Marksteiner M, Jurisch A, Loddenkemper C, Reutzel-Selke A, Sawitzki B*, Pascher A*. Intragraft and Systemic Immune Parameters Discriminating Between Rejection and Longterm Graft Function in a Preclinical Model of Intestinal Transplantation. Transplantation. 2016 Sep 8. [Epub ahead of print] PubMed PMID: 27607529. *equal contribution
  • Farschtschi S, Park SJ, Sawitzki B, Oh SJ, Kluwe L, Mautner VF, Kurtz A. Effector T cell subclasses associate with tumor burden in neurofibromatosis type 1 patients. Cancer Immunol Immunother. 2016 Sep;65(9):1113-21.
  • Gerlach UA, Lachmann N, Ranucci G, Sawitzki B, Schoenemann C, Pratschke J, Dragun D, Pascher A. Non-HLA Antibodies May Accelerate Immune Responses After Intestinal And Multivisceral Transplantation. Transplantation. 2016 Aug 5. [Epub ahead of print] PubMed PMID: 27495766.
  • Arroyo Hornero R, Betts GJ, Sawitzki B, Vogt K, Harden PN, Wood KJ. CD45RA distinguishes CD4+CD25+CD127-/low TSDR demethylated regulatory T cell subpopulations with differential stability and susceptibility to tacrolimus mediated inhibition of suppression. Transplantation. 2016 Jul 28. [Epub ahead of print] PubMed PMID: 27472089.
  • Japp AS, Hoffmann K, Schlickeiser S, Glauben R, Nikolaou C, Maecker HT, Braun J, Matzmohr N, Sawitzki B, Siegmund B, Radbruch A, Volk HD, Frentsch M, Kunkel D, Thiel A. Wild immunology assessed by multidimensional mass cytometry. Cytometry A. 2016 Jul 12. doi: 10.1002/cyto.a.22906. [Epub ahead of print] PubMed PMID: 27403624.
  • von Spee-Mayer C, Siegert E, Abdirama D, Rose A, Klaus A, Alexander T, Enghard P, Sawitzki B, Hiepe F, Radbruch A, Burmester GR, Riemekasten G, Humrich JY. Low-dose interleukin-2 selectively corrects regulatory T cell defects in patients with systemic lupus erythematosus. Ann Rheum Dis. 2016 Jul;75(7):1407-15.
  • Haarer J, Riquelme P, Hoffmann P, Schnitzbauer A, Schlitt HJ, Sawitzki B, Geissler EK, Hutchinson JA. Early Enrichment and Restitution of the Peripheral Blood Treg Pool Is Associated With Rejection-Free Stable Immunosuppression After Liver Transplantation. Transplantation. 2016 Jul;100(7):e39-40.
  • Gerlach UA, Vrakas G, Sawitzki B, Macedo R, Reddy S, Friend PJ, Giele H, Vaidya A. Abdominal Wall Transplantation: Skin as a Sentinel Marker for Rejection. Am J Transplant. 2016 Jun;16(6):1892-900.
  • Kverneland AH, Streitz M, Geissler E, Hutchinson J, Vogt K, Boës D, Niemann N, Pedersen AE, Schlickeiser S, Sawitzki B. Age and gender leucocytes variances and references values generated using the standardized ONE-Study protocol. Cytometry A. 2016 Jun;89(6):543-64.
  • Rohn S, Schroeder J, Riedel H, Polenz D, Stanko K, Reutzel-Selke A, Tang P, Brusendorf L, Raschzok N, Neuhaus P, Pratschke J, Sawitzki B, Sauer IM, Mogl MT. Allogeneic Liver Transplantation and Subsequent Syngeneic Hepatocyte Transplantation in a Rat Model: Proof of Concept for in vivo Tissue Engineering. Cells Tissues Organs. 2016 May 20. [Epub ahead of print] PubMed PMID: 27193603.
  • Bonaccorsi-Riani E, Pennycuick A, Londoño MC, Lozano JJ, Benítez C, Sawitzki B, Martínez-Picola M, Bohne F, Martínez-Llordella M, Miquel R, Rimola A, Sánchez-Fueyo A. Molecular Characterization of Acute Cellular Rejection Occurring During Intentional Immunosuppression Withdrawal in Liver Transplantation. Am J Transplant. 2016 Feb;16(2):484-96.
  • Baas M, Besançon A, Goncalves T, Valette F, Yagita H, Sawitzki B, Volk HD, Waeckel-Enée E, Rocha B, Chatenoud L, You S. TGFβ-dependent expression of PD-1 and PD-L1 controls CD8(+) T cell anergy in transplant tolerance. Elife. 2016 Jan 29;5:e08133.
  • Danger R, Sawitzki B, Brouard S. Immune monitoring in renal transplantation: The search for biomarkers. Eur J Immunol. 2016 Dec;46(12):2695-2704.
  • Sawitzki B. Liver Transplant Patients With Operational Tolerance: What Can the Graft Itself Tell Us? Am J Transplant. 2016 Apr;16(4):1049-50.
  • Schlickeiser S, Streitz M, Sawitzki B. Standardized Multi-Color Flow Cytometry and Computational Biomarker Discovery. Methods Mol Biol. 2016;1371:225-38.

2015

  • Lei H, Kuchenbecker L, Streitz M, Sawitzki B, Vogt K, Landwehr-Kenzel S, Millward J, Juelke K, Babel N, Neumann A, Reinke P, Volk HD. Human CD45RA(-) FoxP3(hi) Memory-Type Regulatory T Cells Show Distinct TCR Repertoires With Conventional T Cells and Play an Important Role in Controlling Early Immune Activation. Am J Transplant. 2015 Oct;15(10):2625-35.
  • Krepsova E, Tycova I, Sekerkova A, Wohlfahrt P, Hruba P, Striz I, Sawitzki B, Viklicky O. Effect of induction therapy on the expression of molecular markers associated with rejection and tolerance. BMC Nephrol. 2015 Aug 19;16:146.
  • Braza F, Dugast E, Panov I, Paul C, Vogt K, Pallier A, Chesneau M, Baron D, Guerif P, Lei H, Laplaud DA, Volk HD, Degauque N, Giral M, Soulillou JP, Sawitzki B, Brouard S. Central Role of CD45RA- Foxp3hi Memory Regulatory T Cells in Clinical Kidney Transplantation Tolerance. J Am Soc Nephrol. 2015 Aug;26(8):1795-805.
  • Schumann J, Stanko K, Schliesser U, Appelt C, Sawitzki B. Differences in CD44 Surface Expression Levels and Function Discriminates IL-17 and IFN-γ Producing Helper T Cells. PLoS One. 2015 Jul 14;10(7):e0132479.
  • Vogel SZ, Schlickeiser S, Jürchott K, Akyuez L, Schumann J, Appelt C, Vogt K, Schröder M, Vaeth M, Berberich-Siebelt F, Lutz MB, Grütz G, Sawitzki B. TCAIM decreases T cell priming capacity of dendritic cells by inhibiting TLR-induced Ca2+ influx and IL-2 production. J Immunol. 2015 Apr 1;194(7):3136-46.
  • Trzonkowski P, Bacchetta R, Battaglia M, Berglund D, Bohnenkamp HR, ten Brinke A, Bushell A, Cools N, Geissler EK, Gregori S, Marieke van Ham S, Hilkens C, Hutchinson JA, Lombardi G, Madrigal JA, Marek-Trzonkowska N, Martinez-Caceres EM, Roncarolo MG, Sanchez-Ramon S, Saudemont A, Sawitzki B. Hurdles in therapy with regulatory T cells. Sci Transl Med. 2015 Sep 9;7(304):304ps18.
  • Schlickeiser S, Boës D, Streitz M, Sawitzki B. The use of novel diagnostics to individualize immunosuppression following transplantation. Transpl Int. 2015 Aug;28(8):911-20.
  • Gaber T, Strehl C, Sawitzki B, Hoff P, Buttgereit F. Cellular energy metabolism in T-lymphocytes. Int Rev Immunol. 2015 Jan;34(1):34-49.
  • Ten Brinke A, Hilkens CM, Cools N, Geissler EK, Hutchinson JA, Lombardi G, Lord P, Sawitzki B, Trzonkowski P, Van Ham SM, Martinez-Caceres EM. Clinical Use of Tolerogenic Dendritic Cells-Harmonization Approach in European Collaborative Effort. Mediators Inflamm. 2015;2015:471719.

Kontakt AG Sawitzki

Prof. Dr. Birgit Sawitzki

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