Auswahl unserer Publikationen

  • Behnam Sani K, Sawitzki B. Immune monitoring as prerequisite for transplantation tolerance trials. Clin Exp Immunol. 2017 Aug;189(2):158-170.
  • Danger R, Sawitzki B, Brouard S. Immune monitoring in renal transplantation: The search for biomarkers. Eur J Immunol. 2016 Dec;46(12):2695-2704.
  • Durek P, Nordström K, Gasparoni G, Salhab A, Kressler C, de Almeida M, Bassler K, Ulas T, Schmidt F, Xiong J, Glažar P, Klironomos F, Sinha A, Kinkley S, Yang X, Arrigoni L, Amirabad AD, Ardakani FB, Feuerbach L, Gorka O, Ebert P, Müller F, Li N, Frischbutter S, Schlickeiser S, Cendon C, Fröhler S, Felder B, Gasparoni N, Imbusch CD, Hutter B, Zipprich G, Tauchmann Y, Reinke S, Wassilew G, Hoffmann U, Richter AS, Sieverling L; DEEP Consortium, Chang HD, Syrbe U, Kalus U, Eils J, Brors B, Manke T, Ruland J, Lengauer T, Rajewsky N, Chen W, Dong J, Sawitzki B, Chung HR, Rosenstiel P, Schulz MH, Schultze JL, Radbruch A, Walter J, Hamann A, Polansky JK. Epigenomic Profiling of Human CD4(+) T Cells Supports a Linear Differentiation Model and Highlights Molecular Regulators of Memory Development. Immunity. 2016 Nov 15;45(5):1148-1161.
  • Bacher P, Heinrich F, Stervbo U, Nienen M, Vahldieck M, Iwert C, Vogt K, Kollet J, Babel N, Sawitzki B, Schwarz C, Bereswill S, Heimesaat MM, Heine G, Gadermaier G, Asam C, Assenmacher M, Kniemeyer O, Brakhage AA, Ferreira F, Wallner M, Worm M, Scheffold A. Regulatory T Cell Specificity Directs Tolerance versus Allergy against Aeroantigens in Humans. Cell. 2016 Nov 3;167(4):1067-1078.e16.
  • Japp AS, Hoffmann K, Schlickeiser S, Glauben R, Nikolaou C, Maecker HT, Braun J, Matzmohr N, Sawitzki B, Siegmund B, Radbruch A, Volk HD, Frentsch M, Kunkel D, Thiel A. Wild immunology assessed by multidimensional mass cytometry. Cytometry A. 2017 Jan;91(1):85-95.
  • Kverneland AH, Streitz M, Geissler E, Hutchinson J, Vogt K, Boës D, Niemann N, Pedersen AE, Schlickeiser S, Sawitzki B. Age and gender leucocytes variances and references values generated using the standardized ONE-Study protocol. Cytometry A. 2016 Jun;89(6):543-64.
  • Baas M, Besançon A, Goncalves T, Valette F, Yagita H, Sawitzki B, Volk HD, Waeckel-Enée E, Rocha B, Chatenoud L, You S. TGFβ-dependent expression of PD-1 and PD-L1 controls CD8(+) T cell anergy in transplant tolerance. Elife. 2016 Jan 29;5:e08133.
  • Schlickeiser S, Streitz M, Sawitzki B. Standardized Multi-Color Flow Cytometry and Computational Biomarker Discovery. Methods Mol Biol. 2016;1371:225-38. doi: 10.1007/978-1-4939-3139-2_15. PubMed PMID: 26530805.
  • Trzonkowski P, Bacchetta R, Battaglia M, Berglund D, Bohnenkamp HR, ten Brinke A, Bushell A, Cools N, Geissler EK, Gregori S, Marieke van Ham S, Hilkens C, Hutchinson JA, Lombardi G, Madrigal JA, Marek-Trzonkowska N, Martinez-Caceres EM, Roncarolo MG, Sanchez-Ramon S, Saudemont A, Sawitzki B. Hurdles in therapy with regulatory T cells. Sci Transl Med. 2015 Sep 9;7(304):304ps18. doi: 10.1126/scitranslmed.aaa7721. Review. PubMed PMID: 26355029.
  • Braza F, Dugast E, Panov I, Paul C, Vogt K, Pallier A, Chesneau M, Baron D, Guerif P, Lei H, Laplaud DA, Volk HD, Degauque N, Giral M, Soulillou JP, Sawitzki B, Brouard S. Central Role of CD45RA- Foxp3hi Memory Regulatory T Cells in Clinical Kidney Transplantation Tolerance. J Am Soc Nephrol. 2015 Aug;26(8):1795-805. doi: 10.1681/ASN.2014050480.
  • Vogel SZ, Schlickeiser S, Jürchott K, Akyuez L, Schumann J, Appelt C, Vogt K, Schröder M, Vaeth M, Berberich-Siebelt F, Lutz MB, Grütz G, Sawitzki B. TCAIM decreases T cell priming capacity of dendritic cells by inhibiting TLR-induced Ca2+ influx and IL-2 production. J Immunol. 2015 Apr 1;194(7):3136-46. doi: 10.4049/jimmunol.1400713.
  • Schumann J, Stanko K, Woertge S, Appelt C, Schumann M, Kühl AA, Panov I, Schliesser U, Vogel S, Ahrlich S, Vaeth M, Berberich-Siebelt F, Waisman A, Sawitzki B. The mitochondrial protein TCAIM regulates activation of T cells and thereby promotes tolerance induction of allogeneic transplants. Am J Transplant. 2014 Dec;14(12):2723-35. doi: 10.1111/ajt.12941.
  • Sherston SN, Vogt K, Schlickeiser S, Sawitzki B, Harden PN, Wood KJ. Demethylation of the TSDR is a marker of squamous cell carcinoma in transplant recipients. Am J Transplant. 2014 Nov;14(11):2617-22. doi: 10.1111/ajt.12899.
  • Sawitzki B, Brunstein C, Meisel C, Schumann J, Vogt K, Appelt C, Curtsinger JM, Verneris MR, Miller JS, Wagner JE, Blazar BR. Prevention of graft-versus-host disease by adoptive T regulatory therapy is associated with active repression of peripheral blood Toll-like receptor 5 mRNA expression. Biol Blood Marrow Transplant. 2014 Feb;20(2):173-82. doi: 10.1016/j.bbmt.2013.10.022.
  • Schliesser U, Chopra M, Beilhack A, Appelt C, Vogel S, Schumann J, Panov I, Vogt K, Schlickeiser S, Olek S, Wood K, Brandt C, Volk HD, Sawitzki B. Generation of highly effective and stable murine alloreactive Treg cells by combined anti-CD4 mAb, TGF-β, and RA treatment. Eur J Immunol. 2013 Dec;43(12):3291-305. doi: 10.1002/eji.201243292.
  • Streitz M, Miloud T, Kapinsky M, Reed MR, Magari R, Geissler EK, Hutchinson JA, Vogt K, Schlickeiser S, Kverneland AH, Meisel C, Volk HD, Sawitzki B. Standardization of whole blood immune phenotype monitoring for clinical trials: panels and methods from the ONE study. Transplant Res. 2013 Oct 25;2(1):17. doi: 10.1186/2047-1440-2-17.
  • Siepert A, Brösel S, Vogt K, Ahrlich S, Schmitt-Knosalla I, Loddenkemper C, Kühl A, Baumgrass R, Gerstmayer B, Tomiuk S, Tiedge M, Viklický O, Brabcova I, Nizze H, Lehmann M, Volk HD, Sawitzki B. Mechanisms and rescue strategies of calcineurin inhibitor mediated tolerance abrogation induced by anti-CD4 mAb treatment. Am J Transplant. 2013 Sep;13(9):2308-21. doi: 10.1111/ajt.12352.
  • Gerlach UA, Vogt K, Schlickeiser S, Meisel C, Streitz M, Kunkel D, Appelt C, Ahrlich S, Lachmann N, Neuhaus P, Pascher A, Sawitzki B. Elevation of CD4+ differentiated memory T cells is associated with acute cellular and antibody-mediated rejection after liver transplantation. Transplantation. 2013 Jun 27;95(12):1512-20. doi: 10.1097/TP.0b013e318290de18.
  • Siepert A, Ahrlich S, Vogt K, Appelt C, Stanko K, Kühl A, van den Brandt J, Reichardt HM, Nizze H, Lehmann M, Tiedge M, Volk HD, Sawitzki B, Reinke P. Permanent CNI treatment for prevention of renal allograft rejection in sensitized hosts can be replaced by regulatory T cells. Am J Transplant. 2012 Sep;12(9):2384-94. doi: 10.1111/j.1600-6143.2012.04143.x.
  • Schlickeiser S, Stanojlovic S, Appelt C, Vogt K, Vogel S, Haase S, Ritter T, Volk HD, Pleyer U, Sawitzki B. Control of TNF-induced dendritic cell maturation by hybrid-type N-glycans. J Immunol. 2011 May 1;186(9):5201-11. doi: 10.4049/jimmunol.1003410.
  • Sagoo P, Perucha E, Sawitzki B, Tomiuk S, Stephens DA, Miqueu P, Chapman S, Craciun L, Sergeant R, Brouard S, Rovis F, Jimenez E, Ballow A, Giral M, Rebollo-Mesa I, Le Moine A, Braudeau C, Hilton R, Gerstmayer B, Bourcier K, Sharif A, Krajewska M, Lord GM, Roberts I, Goldman M, Wood KJ, Newell K, Seyfert-Margolis V, Warrens AN, Janssen U, Volk HD, Soulillou JP, Hernandez-Fuentes MP, Lechler RI. Development of a cross-platform biomarker signature to detect renal transplant tolerance in humans. J Clin Invest. 2010 Jun;120(6):1848-61. doi: 10.1172/JCI39922.
  • Keeren K, Friedrich M, Gebuhr I, Philipp S, Sabat R, Sterry W, Brandt C, Meisel C, Grütz G, Volk HD, Sawitzki B. Expression of tolerance associated gene-1, a mitochondrial protein inhibiting T cell activation, can be used to predict response to immune modulating therapies. J Immunol. 2009 Sep 15;183(6):4077-87. doi: 10.4049/jimmunol.0804351.
  • Gong W, Klöpfel M, Reutzel-Selke A, Jurisch A, Vogt K, Haase S, Höflich C, Polenz D, Gerstmayer B, Tomiuk S, Volk HD, Pascher A, Sawitzki B. High weight differences between donor and recipient affect early kidney graft function—a role for enhanced IL-6 signaling. Am J Transplant. 2009 Aug;9(8):1742-51. doi: 10.1111/j.1600-6143.2009.02725.x.
  • Sawitzki B, Bushell A, Steger U, Jones N, Risch K, Siepert A, Lehmann M, Schmitt-Knosalla I, Vogt K, Gebuhr I, Wood K, Volk HD. Identification of gene markers for the prediction of allograft rejection or permanent acceptance. Am J Transplant. 2007 May;7(5):1091-102. PubMed PMID: 17456197.
  • Sawitzki B, Kingsley CI, Oliveira V, Karim M, Herber M, Wood KJ. IFN-gamma production by alloantigen-reactive regulatory T cells is important for their regulatory function in vivo. J Exp Med. 2005 Jun 20;201(12):1925-35. PubMed PMID: 15967822

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