Auswahl unserer Publikationen

  • Wolk K, Kunz S, Asadullah K, Sabat R. Cutting edge: immune cells as sources and targets of the IL-10 family members? J Immunol 2002 Jun 1; 168(11): 5397-5402.
  • Savoldo B, Huls MH, Liu Z, Okamura T, Volk HD, Reinke P, Sabat R, Babel N, Jones JF, Webster-Cyriaque J, Gee AP, Brenner MK, Heslop HE, Rooney CM. Autologous Epstein-Barr virus (EBV)-specific cytotoxic T cells for the treatment of persistent active EBV infection. Blood 2002 Dec 1; 100(12): 4059-4066.
  • Wolk K, Kunz S, Crompton NE, Volk HD, Sabat R. Multiple Mechanisms of Reduced Major Histocompatibility Complex Class II Expression in Endotoxin Tolerance. J Biol Chem 2003 May 16; 278(20): 18030-18036.
  • Seifert M, Gruenberg BH, Sabat R, Donner P, Gruetz G, Volk HD, Wolk K, Asadullah K. Keratinocyte unresponsiveness towards interleukin-10: lack of specific binding due to deficient IL-10 receptor 1 expression. Exp Dermatol 2003 Apr; 12(2): 137-144.
  • Endesfelder S, Bucher S, Kliche A, Reszka R, Speer A.Transfection of normal primary human skeletal myoblasts with p21 and p57 antisense oligonucleotides to improve their proliferation: a first step towards an alternative molecular therapy approach of Duchenne muscular dystrophy. J Mol Med. 2003 Jun; 81(6): 355-362.
  • Friedrich M, Holzmann R, Sterry W, Wolk K, Truppel A, Piazena H, Schonbein C, Sabat R, Asadullah K. Ultraviolet B radiation-mediated inhibition of interferon-gamma-induced keratinocyte activation is independent of interleukin-10 and other soluble mediators but associated with enhanced intracellular suppressors of cytokine-signaling expression. J Invest Dermatol. 2003 Oct; 121(4): 845-852.
  • Hoflich C, Sabat R, Rosseau S, Temmesfeld B, Slevogt H, Docke WD, Grutz G, Meisel C, Halle E, Gobel UB, Volk HD, Suttorp N. Naturally occurring anti-IFN-gamma autoantibody and severe infections with Mycobacterium cheloneae and Burkholderia cocovenenans. Blood. 2004 Jan 15; 103(2): 673-675.
  • Driessler F, Venstrom K, Sabat R, Asadullah K, Schottelius AJ. Molecular mechanisms of interleukin-10-mediated inhibition of NF-kappaB activity: a role for p50. Clin Exp Immunol. 2004 Jan; 135(1): 64-73.
  • Jung M, Sabat R, Kratzschmar J, Seidel H, Wolk K, Schonbein C, Schutt S, Friedrich M, Docke WD, Asadullah K, Volk HD, Grutz G. Expression profiling of IL-10-regulated genes in human monocytes and peripheral blood mononuclear cells from psoriatic patients during IL-10 therapy. Eur J Immunol. 2004 Feb; 34(2): 481-493.
  • Weiss B, Wolk K, Grunberg BH, Volk HD, Sterry W, Asadullah K, Sabat R. Cloning of murine IL-22 receptor alpha 2 and comparison with its human counterpart. Genes Immun. 2004 Aug; 5(5): 330-336.
  • Wolk K, Kunz S, Witte E, Friedrich, Asadullah K, Sabat R. IL-22 increases the innate immunity of tissues. Immunity 2004 Aug; 21(2): 241-254.
  • Endesfelder S, Kliche A, Lochmüller H, von Moers A, Speer A.Antisense oligonucleotides and short interfering RNAs silencing the cyclin-dependent kinase inhibitor p21 improve proliferation of Duchenne muscular dystrophy patients' primary skeletal myoblasts. J Mol Med. 2005 Jan; 83(1): 64-71.
  • Wolk K, Witte E, Reineke U, Witte K, Friedrich M, Sterry W, Asadullah K, Volk HD, Sabat R. Is there an interaction between interleukin-10 and interleukin-22?. Genes Immun. 2005 Feb; 6(1): 8-18.
  • Wolk K, Grutz G, Witte K, Volk HD, Sabat R. The expression of legumain, an asparaginyl endopeptidase that controls antigen processing, is reduced in endotoxin-tolerant monocytes. Genes Immun. 2005 Aug;6(5):452-456.
  • Stepulak A, Sifringer M, Rzeski W, Endesfelder S, Gratopp A, Pohl EE, Bittigau P, Felderhoff-Mueser U, Kaindl AM, Bührer C, Hansen HH, Stryjecka-Zimmer M, Turski L, Ikonomidou C.NMDA antagonist inhibits the extracellular signal-regulated kinase pathway and suppresses cancer growth. Proc Natl Acad Sci U S A. 2005 Oct 25; 102(43): 15605-15610.
  • Friedrich M, Bock D, Philipp S, Ludwig N, Sabat R, Wolk K, Schroeter-Maas S, Aydt E, Kang S, Dam TN, Zahlten R, Sterry W, Wolff G. Pan-selectin antagonism improves psoriasis manifestation in mice and man. Arch Dermatol Res. 2006 Feb;297(8):345-351.
  • Wolk K, Witte E, Wallace E, Docke WD, Kunz S, Asadullah K, Volk HD, Sterry W, Sabat R. IL-22 regulates the expression of genes responsible for antimicrobial defense, cellular differentiation, and mobility in keratinocytes: a potential role in psoriasis. Eur J Immunol. 2006 May;36(5):1309-23.
  • Wolk K, Sabat R. Interleukin-22: a novel T- and NK-cell derived cytokine that regulates the biology of tissue cells. Cytokine Growth Factor Rev. 2006 Oct;17(5):367-80.
  • Bulwin GC, Heinemann T, Bugge V, Winter M, Lohan A, Schlawinsky M, Schulze A, Walter S, Sabat R, Schulein R, Wiesner B, Veh RW, Lohler J, Blumberg RS, Volk HD, Utku N. TIRC7 inhibits T cell proliferation by modulation of CTLA-4 expression. J Immunol. 2006 Nov 15;177(10):6833-41.
  • Kunz S, Wolk K, Witte E, Witte K, Doecke WD, Volk HD, Sterry W, Asadullah K, Sabat R. Interleukin (IL)-19, IL-20 and IL-24 are produced by and act on keratinocytes and are distinct from classical ILs. Exp Dermatol. 2006 Dec;15(12):991-1004.
  • Philipp S, Wolk K, Kreutzer S, Wallace E, Ludwig N, Roewert J, Hoflich C, Volk HD, Sterry W, Sabat R. The evaluation of psoriasis therapy with biologics leads to a revision of the current view of the pathogenesis of this disorder. Expert Opin Ther Targets. 2006 Dec;10(6):817-31.
  • Ambuhl PM, Tissot AC, Fulurija A, Maurer P, Nussberger J, Sabat R, Nief V, Schellekens C, Sladko K, Roubicek K, Pfister T, Rettenbacher M, Volk HD, Wagner F, Muller P, Jennings GT, Bachmann MF. A vaccine for hypertension based on virus-like particles: preclinical efficacy and phase I safety and immunogenicity. J Hypertens. 2007 Jan;25(1):63-72.
  • Wolk K, Hoflich C, Zuckermann-Becker H, Docke WD, Volk HD, Sabat R. Reduced monocyte CD86 expression in postinflammatory immunodeficiency. Crit Care Med. 2007 Feb;35(2):458-67.
  • Wolk K, Witte E, Hoffmann U, Doecke WD, Endesfelder S, Asadullah K, Sterry W, Volk HD, Wittig BM, Sabat R. IL-22 induces lipopolysaccharide-binding protein in hepatocytes: a potential systemic role of IL-22 in Crohn's disease. J Immunol. 2007 May 1;178(9):5973-81.
  • Sabat R, Wallace E, Endesfelder S, Wolk K. IL-19 and IL-20: two novel cytokines with importance in inflammatory diseases. Expert Opin Ther Targets. 2007 May;11(5):601-12.
  • Sabat R, Philipp S, Höflich C, Kreutzer S, Wallace E, Asadullah K, Volk HD, Sterry W, Wolk K. Immunopathogenesis of psoriasis. Exp Dermatol. 2007 Oct; 16 (10), 779-798.
  • Lingnau M, Hoflich C, Volk HD, Sabat R, Docke WD. Interleukin-10 enhances the CD14-dependent phagocytosis of bacteria and apoptotic cells by human monocytes. Hum Immunol. 2007 Sep;68(9):730-8.

Kontakt Molekulare Immunpathologie

Dr. med.
Robert Sabat

Charité – Universitätsmedizin Berlin
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Dermatologie
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