Publikationen des Psoriasis-Forschungs- und BehandlungsCentrums

Das Psoriasis-Forschungs- und BehandlungsCentrum unter Leitung von PD Dr. med. Robert Sabat ist ein interdisziplinäres Zentrum des Instituts für Medizinische Immunologie und der Klinik für Dermatologie, Venerologie und Allergologie der Charité.

Auf dieser Seite finden Sie eine Auswahl der Publikationen des Zentrums.

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Eine Auswahl der Publikationen des Psoriasis-Forschungs- und BehandlungsCentrums

  • Witte-Händel E, Wolk K, Tsaousi A, Irmer ML, Mößner R, Shomroni O, Lingner T, Witte K, Kunkel D, Salinas G, Jodl S, Schmidt N, Sterry W, Volk HD, Giamarellos-Bourboulis EJ, Pokrywka A, Döcke WD, Schneider-Burrus S, Sabat R. The IL-1 Pathway Is Hyperactive in Hidradenitis Suppurativa and Contributes to Skin Infiltration and Destruction. J Invest Dermatol. 2018 Dec 5. pii: S0022-202X(18)32909-9. doi: 10.1016/j.jid.2018.11.018.
  • Krause K, Sabat R, Witte-Händel E, Schulze A, Puhl V, Maurer M, Wolk K. Association of CCL2 with systemic inflammation in Schnitzler syndrome. Br J Dermatol. 2019 Apr;180(4):859-868. doi: 10.1111/bjd.17334.
  • Wittig BM, Sabat R, Holzlöhner P, Witte-Händel E, Heilmann K, Witte K, Triebus J, Tzankov A, Laman JD, Bokemeyer B, Terracciano L, Schwärzler C, Kohler H, Volkmer R, Loddenkemper C, Wolk K, Hoffmann U, Günthert U. Absence of specific alternatively spliced exon of CD44 in macrophages prevents colitis. Mucosal Immunol. 2018 May;11(3):846-860. doi: 10.1038/mi.2017.98.
  • Zouboulis CC, Tzellos T, Kyrgidis A, Jemec GBE, Bechara FG, Giamarellos-Bourboulis EJ, Ingram JR, Kanni T, Karagiannidis I, Martorell A, Matusiak Ł, Pinter A, Prens EP, Presser D, Schneider-Burrus S, von Stebut E, Szepietowski JC, van der Zee HH, Wilden SM, Sabat R; European Hidradenitis Suppurativa Foundation Investigator Group. Development and validation of the International Hidradenitis Suppurativa Severity Score System (IHS4), a novel dynamic scoring system to assess HS severity. Br J Dermatol. 2017 Nov;177(5):1401-1409. doi: 10.1111/bjd.15748.
  • Martin JC*, Wolk K*, Bériou G, Abidi A, Witte-Händel E, Louvet C, Kokolakis G, Drujont L, Dumoutier L, Renauld JC, Sabat R*, Josien R*. Limited Presence of IL-22 Binding Protein, a Natural IL-22 Inhibitor, Strengthens Psoriatic Skin Inflammation. J Immunol. 2017 May 1;198(9):3671-3678. doi: 10.4049/jimmunol.1700021.
  • Wolk K, Wenzel J, Tsaousi A, Witte-Händel E, Babel N, Zelenak C, Volk HD, Sterry W, Schneider-Burrus S, Sabat R. Lipocalin-2 is expressed by activated granulocytes and keratinocytes in affected skin and reflects disease activity in acne inversa/hidradenitis suppurativa. Br J Dermatol. 2017 Nov;177(5):1385-1393. doi: 10.1111/bjd.15424.
  • Wolk K, Sabat R. Adipokines in psoriasis: An important link between skin inflammation and metabolic alterations. Rev Endocr Metab Disord. 2016 Sep;17(3):305-317.
  • Witte E, Kokolakis G, Witte K, Warszawska K, Friedrich M, Christou D, Kirsch S, Sterry W, Volk HD, Sabat R, Wolk K. Interleukin-29 induces epithelial production of CXCR3A ligands and T-cell infiltration. J Mol Med (Berl). 2016 Apr;94(4):391-400. doi: 10.1007/s00109-015-1367-y.
  • von Haehling S, Wolk K, Höflich C, Kunz S, Grünberg BH, Döcke WD, Reineke U, Asadullah K, Sterry W, Volk HD, Sabat R. Interleukin-10 receptor-1 expression in monocyte-derived antigen-presenting cell populations: dendritic cells partially escape from IL-10's inhibitory mechanisms. Genes Immun. 2015 Jan-Feb;16(1):8-14. doi: 10.1038/gene.2014.69.
  • Wolk K, Mitsui H, Witte K, Gellrich S, Gulati N, Humme D, Witte E, Gonsior M, Beyer M, Kadin ME, Volk HD, Krueger JG, Sterry W, Sabat R. Deficient cutaneous antibacterial competence in cutaneous T-cell lymphomas: role of Th2-mediated biased Th17 function. Clin Cancer Res. 2014 Nov 1;20(21):5507-16. doi: 10.1158/1078-0432.CCR-14-0707.
  • Witte E, Kokolakis G, Witte K, Philipp S, Doecke WD, Babel N, Wittig BM, Warszawska K, Kurek A, Erdmann-Keding M, Kunz S, Asadullah K, Kadin ME, Volk HD, Sterry W, Wolk K, Sabat R. IL-19 is a component of the pathogenetic IL-23/IL-17 cascade in psoriasis. J Invest Dermatol. 2014 Nov;134(11):2757-2767. doi: 10.1038/jid.2014.308.
  • Sabat R, Ouyang W, Wolk K. Therapeutic opportunities of the IL-22-IL-22R1 system. Nat Rev Drug Discov. 2014 Jan;13(1):21-38. doi: 10.1038/nrd4176.
  • Wolk K, Witte K, Witte E, Raftery M, Kokolakis G, Philipp S, Schönrich G, Warszawska K, Kirsch S, Prösch S, Sterry W, Volk HD, Sabat R. IL-29 is produced by T(H)17 cells and mediates the cutaneous antiviral competence in psoriasis. Sci Transl Med. 2013 Sep 25;5(204):204ra129. doi: 10.1126/scitranslmed.3006245.
  • Kumari S, Bonnet MC, Ulvmar MH, Wolk K, Karagianni N, Witte E, Uthoff-Hachenberg C, Renauld JC, Kollias G, Toftgard R, Sabat R, Pasparakis M, Haase I. Tumor necrosis factor receptor signaling in keratinocytes triggers interleukin-24-dependent psoriasis-like skin inflammation in mice. Immunity. 2013 Nov 14;39(5):899-911. doi: 10.1016/j.immuni.2013.10.009
  • Sabat R, Chanwangpong A, Schneider-Burrus S, Metternich D, Kokolakis G, Kurek A, Philipp S, Uribe D, Wolk K, Sterry W. Increased prevalence of metabolic syndrome in patients with acne inversa. PLoS One. 2012;7(2):e31810. doi: 10.1371/journal.pone.0031810.
  • Wolk K, Warszawska K, Hoeflich C, Witte E, Schneider-Burrus S, Witte K, Kunz S, Buss A, Roewert HJ, Krause M, Lukowsky A, Volk HD, Sterry W, Sabat R. Deficiency of IL-22 contributes to a chronic inflammatory disease: pathogenetic mechanisms in acne inversa. J Immunol. 2011 Jan 15;186(2):1228-39. doi: 10.4049/jimmunol.0903907.
  • Muñoz M, Heimesaat MM, Danker K, Struck D, Lohmann U, Plickert R, Bereswill S, Fischer A, Dunay IR, Wolk K, Loddenkemper C, Krell HW, Libert C, Lund LR, Frey O, Hölscher C, Iwakura Y, Ghilardi N, Ouyang W, Kamradt T, Sabat R, Liesenfeld O. Interleukin (IL)-23 mediates Toxoplasma gondii-induced immunopathology in the gut via matrixmetalloproteinase-2 and IL-22 but independent of IL-17. J Exp Med. 2009 Dec 21;206(13):3047-59. doi: 10.1084/jem.20090900.
  • Wolk K, Witte E, Warszawska K, Schulze-Tanzil G, Witte K, Philipp S, Kunz S, Döcke WD, Asadullah K, Volk HD, Sterry W, Sabat R. The Th17 cytokine IL-22 induces IL-20 production in keratinocytes: a novel immunological cascade with potential relevance in psoriasis. Eur J Immunol. 2009 Dec;39(12):3570-81. doi: 10.1002/eji.200939687.
  • Witte K, Gruetz G, Volk HD, Looman AC, Asadullah K, Sterry W, Sabat R, Wolk K. Despite IFN-lambda receptor expression, blood immune cells, but not keratinocytes or melanocytes, have an impaired response to type III interferons: implications for therapeutic applications of these cytokines. Genes Immun. 2009 Dec;10(8):702-14. doi: 10.1038/gene.2009.72.
  • Wolk K*, Haugen HS*, Xu W, Witte E, Waggie K, Anderson M, Vom Baur E, Witte K, Warszawska K, Philipp S, Johnson-Leger C, Volk HD, Sterry W, Sabat R. IL-22 and IL-20 are key mediators of the epidermal alterations in psoriasis while IL-17 and IFN-gamma are not. J Mol Med (Berl). 2009 May;87(5):523-36. doi: 10.1007/s00109-009-0457-0.
  • Wolk K, Höflich C, Zuckermann-Becker H, Döcke WD, Volk HD, Sabat R. Reduced monocyte CD86 expression in postinflammatory immunodeficiency. Crit Care Med. 2007 Feb;35(2):458-67.
  • Wolk K, Witte E, Wallace E, Döcke WD, Kunz S, Asadullah K, Volk HD, Sterry W, Sabat R. IL-22 regulates the expression of genes responsible for antimicrobial defense, cellular differentiation, and mobility in keratinocytes: a potential role in psoriasis. Eur J Immunol. 2006 May;36(5):1309-23.
  • Weiss B*, Wolk K*, Grünberg BH, Volk HD, Sterry W, Asadullah K, Sabat R. Cloning of murine IL-22 receptor alpha 2 and comparison with its human counterpart. Genes Immun. 2004 Aug;5(5):330-6.
  • Wolk K, Kunz S, Witte E, Friedrich M, Asadullah K, Sabat R. IL-22 increases the innate immunity of tissues. Immunity. 2004 Aug;21(2):241-54.

Kontakt Psoriasis Forschungs- und BehandlungsCentrum

PD Dr. med. Robert Sabat (Leiter des Zentrums)

CharitéUniversitätsmedizin Berlin
Campus Charité Mitte
Edmund-Lesser-Haus (Hautklinik)
Luisenstr. 2
10117 Berlin

Postanschrift:
Charitéplatz 1
10117 Berlin

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